Informace o projektu
Czech Infrastructure for Integrative Structural Biology
(CIISB)
- Kód projektu
- LM2015043
- Období řešení
- 1/2016 - 12/2019
- Investor / Programový rámec / typ projektu
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Ministerstvo školství, mládeže a tělovýchovy ČR
- Velké infrastruktury pro výzkum, vývoj a inovace
- Fakulta / Pracoviště MU
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Středoevropský technologický institut
- prof. RNDr. Vladimír Sklenář, DrSc.
The Czech Infrastructure for Integrative Structural Biology (CIISB) is a distributed infrastructure of the core facilities and central laboratories of CEITEC (Central European Institute of Technology, Brno) and BIOCEV (Biotechnology and Biomedicine Centre, Vestec, Prague-West) providing expertise and access to technologies used for integrative approaches to structural analysis of biologically important cellular components and macromolecules - proteins, nucleic acids, and their complexes. CIISB, equipped with the cutting-edge technologies (total investments will exceed 750 mil. CZK by the end of 2015), will offer access to the equipment and expertise in the following fields: high-field NMR spectroscopy; high throughput crystallization of biological macromolecules; X-ray diffraction techniques; Bio-SAXS measurements; AFM imaging; characterization of proteins, nucleic acids and complexes by biophysical methods including microcalorimetry, dynamic light scattering, and surface plasmon resonance; high-end cryo-electron microscopy and tomography allowing studies of cellular structures, organelles, and biomacromolecular complexes by 3D imaging; protein expression in eukaryotic cells; high-end mass spectrometry characterization of biomacromolecules; determination of protein post-translational modifications; MS-based peptide mapping/sequencing; high throughput sequencing and proteomic services. CIISB infrastructure aims to provide a high quality open access services in provision of methods and techniques on a level of national and trans-national importance. CIISB as National Affiliated Center is a part of the ESFRI projects INSTRUCT.
Publikace
Počet publikací: 251
2018
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Summer School on New Approaches in Experimental Biology
Rok: 2018, druh: Popularizační texty
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Symposium on recent advances in cryo-electron microscopy
Rok: 2018, druh: Uspořádání konference
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Synthesis of a-L-fucopyranoside-presenting glycoclusters and investigation of their interaction with recombinant Photorhabdus asymbiotica lectin (PHL)
Chemistry - A European Journal, rok: 2018, ročník: 24, vydání: 16, DOI
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Synthesis of dibenzocyclooctadiene lignans derivatives as P-glycoprotein inhibitors
Rok: 2018, druh: Konferenční abstrakty
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The Diverged Trypanosome MICOS Complex as a Hub for Mitochondrial Cristae Shaping and Protein Import
Current Biology, rok: 2018, ročník: 28, vydání: 21, DOI
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The Structural Properties in Solution of the Intrinsically Mixed Folded Protein Ataxin-3
Biophysical Journal, rok: 2018, ročník: 115, vydání: 1, DOI
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Thermodynamics of Halide Binding to a Neutral Bambusuril in Water and Organic Solvents
Journal of Organic Chemistry, rok: 2018, ročník: 83, vydání: 4, DOI
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Through-Space Paramagnetic NMR Effects in Host-Guest Complexes: Potential Ruthenium(III) Metallodrugs with Macrocyclic Carriers
Inorganic Chemistry, rok: 2018, ročník: 57, vydání: 15, DOI
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Time-Dependent Growth of Silica Shells on CdTe Quantum Dots
Nanomaterials, rok: 2018, ročník: 8, vydání: 6, DOI
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Unsubstituted Bambusurils: Post-Macrocyclization Modification of Versatile Intermediates
ACS Omega, rok: 2018, ročník: 3, vydání: 4, DOI