Synthesis and tautomerism study of 7-substituted pyrazolo[3,4-c]pyridines

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Authors	KOURAFALOS Vassilios N. MARAKOS Panagiotis MIKROS Emmanuel POULI Nicole MAREK Jaromír MAREK Radek
Year of publication	2006
Type	Article in Periodical
Magazine / Source	Tetrahedron
MU Faculty or unit	Faculty of Science
Citation
Web	http://www.sciencedirect.com/science/journal/00404020
Field	Organic chemistry
Keywords	pyrazolo[3;4-c]pyridine; tautomerism; NMR spectroscopy; X-ray diffraction
Description	A number of 7-substituted pyrazolo[3,4-c]pyridine derivatives have been synthesized in order to investigate the N1–N2 tautomerism within this class of biologically interesting compounds. Tautomeric equilibrium has been studied using NMR 13C, 15N chemical shifts and heteronuclear 1H–15N and 1H–13C spin–spin couplings, in conjunction with X-ray crystallography. The N1 tautomer predominates in DMF solution in all the compounds tested.
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