Type I iodothyronine 5’-deiodinase mRNA and activity is increased in adipose tissue of obese subjects

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Authors

ORTEGA F. J. JÍLKOVÁ Z. M. MORENO-NAVARRETE J. M. PAVELKA Stanislav RODRIGUEZ-HERMOSA J. I. KOPECKÝ Jan FERNÁNDEZ-REAL J. M.

Year of publication 2012
Type Article in Periodical
Magazine / Source International Journal of Obesity
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.nature.com/ijo/journal/v36/n2/full/ijo2011101a.html
Doi http://dx.doi.org/10.1038/ijo.2011.101
Field Endocrinology, diabetology, metabolism, nutrition
Keywords Adipose tissue; thyroid hormones; deiodinases; tissue expression; enzyme activity
Description Expression of the genes for type I iodothyronine 5'-deiodinase (D1), leptin (LEP) and stearoyl-CoA desaturase 1 (SCD-1) was evaluated in omental (OM) and subcutaneous (SC) fat using a cohort of 70 humans. Activities of iodothyronine deiodinases (D1, D2 and D3) were assessed in a randomly selected subpopulation of 19 subjects.
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