Natural Compound Cudraflavone B Shows Promising Anti-inflammatory Properties in Vitro

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Authors

HOŠEK Jan BARTOS Milan CHUDÍK Stanislav DALL’ACQUA Stefano INNOCENTI Gabbriella KARTAL Murat KOKOŠKA Ladislav KOLLÁR Peter KUTIL Zsófia LANDA Přemysl MAREK Radek ZÁVALOVÁ Veronika ŽEMLIČKA Milan ŠMEJKAL Karel

Year of publication 2011
Type Article in Periodical
Magazine / Source Journal of Natural Products
MU Faculty or unit

Central European Institute of Technology

Citation
Web DOI: 10.1021/np100638h
Doi http://dx.doi.org/10.1021/np100638h
Field Biochemistry
Keywords Cudraflavone; Morus alba; anti-inflammatory; zinc-finger protein; nonsteroidal drug lead
Attached files
Description Cudraflavone B (1) is a prenylated flavonoid found in large amounts in the roots of Morus alba, a plant used as a herbal remedy for its reputed anti-inflammatory properties. The present study shows that this compound causes a significant inhibition of inflammatory mediators in selected in vitro models. Thus, 1 was identified as a potent inhibitor of tumor necrosis factor R (TNFR) gene expression and secretion by blocking the translocation of nuclear factor kB (NF-kB) from the cytoplasm to the nucleus inmacrophages derived from a THP-1 human monocyte cell line. Compound 1 acts as a cyclooxygenase (COX-2 and COX-1) inhibitor with higher selectivity toward COX-2 than indomethacin. Pretreatment of cells by 1 shifted the peak in an regulatory gene zinc-finger protein 36 (ZFP36) expression assay. This natural product has noticeable antiinflammatory properties, suggesting that 1 potentially could be used for development as a nonsteroidal anti-inflammatory drug lead.
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