Project information
Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine
- Project Identification
- LC06035
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
- Faculty of Science
- Keywords
- nukleové kyseliny, proteiny, karcinogeny, léčiva, poškození DNA, hybridizace DNA, interakce DNA-protein, nádorové supresory, amyloidní proteiny, mutantní proteiny, denaturace, agregace, elektrochemie, separace, kapilární elektroforéza, hmotová spektromet
- Cooperating Organization
-
Institute of Biophysics
Charles University
University of Pardubice
Masaryk Memorial Cancer Institute Brno
After completion of the human genome project, there is demand for simple and inexpensive methods enabling analysis of details of individuals' genomes. The contemporary world science is oriented towards utilization of electrochemical DNA detection in thisanalysis. DNA electroactivity was discovered at the Institute of Biophysics in Brno. Laboratories of this Institute belong to the world elite in this field for more than four decades. In the partner laboratories, a considerable progress has been attainedin the research of electrochemical DNA sensors as well as in analysis of proteins and other substances in recent years. This project is based on the existing results and it is oriented towards advanced studies of the properties of biomacromolecules andt heir interactions with surfaces, especially electrodes, and towards research of intermolecular interactions of DNA and/or proteins important in severe disorders (cancer, Parkinson's or Alzheimer's disease). On the basis of electrochemistry, miniaturiza
Publications
Total number of publications: 228
2010
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Time-resolved luminescence spectroscopy as a tool for study of reaction mechanisms
Abstract Book of XIV. International Symposium on Luminescence Spectrometry, year: 2010
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Two-dimensional condensation of nucleic acids components – how it was discovered 45 years ago and contemporary investigations
Year: 2010, type: Conference abstract
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Voltammetric Study of Aminopurines on Pencil Graphite Electrode in the Presence of Copper Ions
Electroanalysis, year: 2010, volume: 22, edition: 15
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Využití paramagnetických částic pro izolaci oligonukleotidů s různou sekvencí a délkou řetězce
XXX. moderní elektrochemické metody - sborník přednášek, year: 2010
2009
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An employment of electrochemical methods in nanotechnologies
Vitamins, Nutrition, Diagnostics 2009 - the abstract book, year: 2009
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Biomarker discovery in low-grade breast cancer using isobaric stable isotope tags and two-dimensional liquid chromatography-tandem mass spectrometry (iTRAQ-2DLC-MS/MS) based quantitative proteomic analysis
Journal of Proteome Research, year: 2009, volume: 8, edition: 1, DOI
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Deoxyschizandrin and gama-schizandrin restore the cytotoxic action of doxorubicin in multi-drug resistant lung cancer cells COR-L23/R
Book of Abstract of Conference of Functional Molecules from Natural Sources, year: 2009
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Dependence of adenine isolation efficiency on the chain length evidenced using paramagnetic particles and voltammetry measurements
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS, year: 2009, volume: 321, edition: 10
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Determination of Heavy Metals in Wine by Stripping Techniques Using a Bismuth Film Deposited on a Carbon Screen-Printed Electrode
IX. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2009
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Dibenzocyclooctadiene lignans overcome drug resistance in lung cancer cells - Study of structure-activity relationship
Toxicology in Vitro, year: 2009, volume: 23, edition: 6