Project information
Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine
- Project Identification
- LC06035
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
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Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
- Faculty of Science
- Keywords
- nukleové kyseliny, proteiny, karcinogeny, léčiva, poškození DNA, hybridizace DNA, interakce DNA-protein, nádorové supresory, amyloidní proteiny, mutantní proteiny, denaturace, agregace, elektrochemie, separace, kapilární elektroforéza, hmotová spektromet
- Cooperating Organization
-
Institute of Biophysics
Charles University
University of Pardubice
Masaryk Memorial Cancer Institute Brno
After completion of the human genome project, there is demand for simple and inexpensive methods enabling analysis of details of individuals' genomes. The contemporary world science is oriented towards utilization of electrochemical DNA detection in thisanalysis. DNA electroactivity was discovered at the Institute of Biophysics in Brno. Laboratories of this Institute belong to the world elite in this field for more than four decades. In the partner laboratories, a considerable progress has been attainedin the research of electrochemical DNA sensors as well as in analysis of proteins and other substances in recent years. This project is based on the existing results and it is oriented towards advanced studies of the properties of biomacromolecules andt heir interactions with surfaces, especially electrodes, and towards research of intermolecular interactions of DNA and/or proteins important in severe disorders (cancer, Parkinson's or Alzheimer's disease). On the basis of electrochemistry, miniaturiza
Publications
Total number of publications: 228
2010
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Lanthanide(III) Complexes of 4,10-Bis(phosphonomethyl)-1,4,7,10-tetraazacyclododecane-1,7-diacetic acid (trans-H6do2a2p) in Solution and in the Solid State: Structural Studies Along the Series
Chemistry - A European Journal, year: 2010, volume: 16, edition: 28
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Laser ablation of ternary As-S-Se glasses and clusters analysis by time of flight mass spectrometry
Rapid Commun. Mass Spectrom, year: 2010, volume: 24, edition: 1
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Laser desorption ionization time-of-flight mass spectrometric study of binary As-Se glasses
Rapid Communications in Mass Spectrometry, year: 2010, volume: 24, edition: 24, 2010
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LC with off-line MALDI mass spectrometry for analysis of bioactive compounds
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010
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MEMBRANE ASSISTED FABRICATION OF COPPER NANOSTRUCTURES AND THEIR CHARACTERIZATION
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010
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METODY V ZÁZNAMU, HODNOCENÍ A ZPRACOVÁNÍ GENOMICKÝCH SIGNÁLŮ FRAKTÁLY
XIV.Setkání biochemiků a molekulárních biologů - sborník příspěvků, year: 2010
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Polyaniline Sulfonate/Cytochrome c Multilayer Electrodes: Polyelectrolytes Properties and Assembly Characteristics
Year: 2010, type: Appeared in Conference without Proceedings
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POSSIBILITIES OF IMPLEMENTATION OF ELIMINATION VOLTAMMETRY IN ELECTROCHEMICAL ANALYZERS
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010
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Potenciometrická studie fyziologicky významných derivátů adeninu
XXX. moderní elektrochemické metody - sborník přednášek, year: 2010
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POWER SPECTRUM METHOD IN RECORD, EVALUATION AND PROCESSING OF GENOMIC SIGNALS
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010