Project information
Centre of Biophysical Chemistry, Bioelectrochemistry and Bioanalysis. New Tools for Genomics, Proteomics and Biomedicine
- Project Identification
- LC06035
- Project Period
- 3/2006 - 12/2011
- Investor / Pogramme / Project type
-
Ministry of Education, Youth and Sports of the CR
- Basic Research Center
- MU Faculty or unit
- Faculty of Science
- Keywords
- nukleové kyseliny, proteiny, karcinogeny, léčiva, poškození DNA, hybridizace DNA, interakce DNA-protein, nádorové supresory, amyloidní proteiny, mutantní proteiny, denaturace, agregace, elektrochemie, separace, kapilární elektroforéza, hmotová spektromet
- Cooperating Organization
-
Institute of Biophysics
Charles University
University of Pardubice
Masaryk Memorial Cancer Institute Brno
After completion of the human genome project, there is demand for simple and inexpensive methods enabling analysis of details of individuals' genomes. The contemporary world science is oriented towards utilization of electrochemical DNA detection in thisanalysis. DNA electroactivity was discovered at the Institute of Biophysics in Brno. Laboratories of this Institute belong to the world elite in this field for more than four decades. In the partner laboratories, a considerable progress has been attainedin the research of electrochemical DNA sensors as well as in analysis of proteins and other substances in recent years. This project is based on the existing results and it is oriented towards advanced studies of the properties of biomacromolecules andt heir interactions with surfaces, especially electrodes, and towards research of intermolecular interactions of DNA and/or proteins important in severe disorders (cancer, Parkinson's or Alzheimer's disease). On the basis of electrochemistry, miniaturiza
Publications
Total number of publications: 228
2010
-
ELECTROCHEMICAL STUDY OF HEPTAOLIGONUCLEOTIDES
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010
-
Elektrochemická charakterizace krátkých oligonukleotidů
XXX. moderní elektrochemické metody - sborník přednášek, year: 2010
-
Elimination Procedure as a Novel and Promising Mathematical Approach in Voltammetric Methods.
Electroanalysis, year: 2010, volume: 22, edition: 17-18
-
Elimination voltammetry as a powerful electrochemical tool for improving voltammetric results
Year: 2010, type: Appeared in Conference without Proceedings
-
Elimination Voltammetry of Miniaturized Mercury Drop Electrodes
Electroanalysis, year: 2010, volume: 22, edition: 16
-
Gas plasmas and plasma modified materials in medicine
Journal of Applied Biomedicine, year: 2010, volume: 8, edition: 2
-
Gelová elektroforéza osmiem značených oligonukleotidů s následnou detekcí kovu pomocí LA-ICP-MS
Sborník 14. česko – slovenské spektroskopické konference, year: 2010
-
Gold(III) and nanogold interaction with Humic acids: Spectrophotometry, Capillary electrophoresis and mass spectrometric study
15th IHSS MEETING "Humic Substances and the Maintenance of Ecosystem Services", THE WORLD CONFERENCE ON HUMIC SUBSTANCES & NATURAL ORGANIC MATTER, year: 2010
-
CHROMATOGRAPHIC STUDY OF PROTONATION OF PURINE DERIVATES
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010
-
Lanthanide Luminescence
X. pracovní setkání fyzikálních chemiků a elektrochemiků - sborník příspěvků, year: 2010