Bone marrow plasma cell separation - validation of separation algorithm

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Authors

BUREŠOVÁ Ivana ČUMOVÁ Jana ŘÍHOVÁ Lucie STOSSOVA Jana DEMENTYEVA Elena Vladimirovna KRYUKOV Fedor ŠEVČÍKOVÁ Sabina ŠVÁCHOVÁ Hana HÁJEK Roman

Year of publication 2012
Type Article in Periodical
Magazine / Source Clinical Chemistry and Laboratory medicine
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1515/cclm-2012-8837
Field Oncology and hematology
Keywords FACS; MACS; monoclonal gammopathy; multiple myeloma; plasma cell
Attached files
Description Monoclonal gammopathy is characterized by the presence of monoclonal immunoglobulin which is produced by a specifi c clone of terminally differentiated long-living plasma cells (PC) in the bone marrow. More detailed understanding of this clone at the genomic and proteomic level as well as its comparison with the population of normal PC is possible only after the clone is separated from other BM cells.
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