Complete genome sequence of Treponema pallidum strain DAL-1

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Authors

ZOBANÍKOVÁ Marie MIKOLKA Pavol ČEJKOVÁ Darina POSPÍŠILOVÁ Petra CHEN Lei STROUHAL Michal QIN Xiang WEINSTOCK George M. ŠMAJS David

Year of publication 2012
Type Article in Periodical
Magazine / Source Standards in Genomic Sciences
MU Faculty or unit

Faculty of Medicine

Citation
Web http://standardsingenomics.org/index.php/sigen/article/view/sigs.2615838/784
Doi http://dx.doi.org/10.4056/sigs.2615838
Field Genetics and molecular biology
Keywords Spirochaetaceae; Treponema pallidum; syphilis
Description Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.
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