Complete genome sequence of Treponema pallidum strain DAL-1

• Authors: ZOBANÍKOVÁ Marie; MIKOLKA Pavol; ČEJKOVÁ Darina; POSPÍŠILOVÁ Petra; CHEN Lei; STROUHAL Michal; QIN Xiang; WEINSTOCK George M.; ŠMAJS David
• Year of publication: 2012
• Type: Article in Periodical
• Magazine / Source: Standards in Genomic Sciences
• MU Faculty or unit: Faculty of Medicine
• Web: http://standardsingenomics.org/index.php/sigen/article/view/sigs.2615838/784
• Doi: http://dx.doi.org/10.4056/sigs.2615838
• Field: Genetics and molecular biology
• Keywords: Spirochaetaceae; Treponema pallidum; syphilis
• Description: Treponema pallidum strain DAL-1 is a human uncultivable pathogen causing the sexually transmitted disease syphilis. Strain DAL-1 was isolated from the amniotic fluid of a pregnant woman in the secondary stage of syphilis. Here we describe the 1,139,971 bp long genome of T. pallidum strain DAL-1 which was sequenced using two independent sequencing methods (454 pyrosequencing and Illumina). In rabbits, strain DAL-1 replicated better than the T. pallidum strain Nichols. The comparison of the complete DAL-1 genome sequence with the Nichols sequence revealed a list of genetic differences that are potentially responsible for the increased rabbit virulence of the DAL-1 strain.

Related projects

• Molecular basis of cell and tissue regulations
• Komparativní genomové sekvencování patogenních treponem a transkriptomová analýza T. pallidum ssp. pallidum