Invasive mould disease involving the gastrointestinal tract caused by Neosartorya pseudofischeri in a haematological patient
| Authors | |
|---|---|
| Year of publication | 2013 |
| Type | Article in Periodical |
| Magazine / Source | Mycoses |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1111/myc.12038 |
| Field | Oncology and hematology |
| Keywords | PULMONARY ASPERGILLOSIS; FUNGAL PATHOGENS; IDENTIFICATION; GALACTOMANNAN; PCR; INFECTIONS; ANAMORPH |
| Attached files | |
| Description | Invasive mould diseases (IMD) are serious, life-threatening complications in immunocompromised hosts. Patients with acute myeloid leukaemia (AML) as well as those after allogeneic bone marrow transplantation represent the highest risk group, with an IMD incidence of approximately 10%. Invasive aspergillosis (IA) is the most frequent type and represents 96% of all IMD cases. The incidence of IA in this high-risk group of patients is 10% and the mortality is 30–40%.1 In more than 90% of IA cases, the lungs are affected or the disease is disseminated. Importantly, isolated gastrointestinal involvement is very uncommon.2 Molecular techniques have been used in the diagnosis and identification of mould diseases and new fungal species morphologically similar to Aspergillus fumigatus have been described. The Aspergillus section Fumigati now includes anamorphic Aspergillus species and teleomorphic Neosartorya species. Neosartorya spp. is a filamentous fungus that is commonly found in soil throughout the world. Invasive mould infections caused by Neosartorya spp. have very rarely been described in literature. |
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