Default Mode Network and Extrastriate Visual Resting State Network in Patients with Parkinson's Disease Dementia
| Authors | |
|---|---|
| Year of publication | 2012 |
| Type | Article in Periodical |
| Magazine / Source | Neurodegenerative Diseases |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.karger.com/Article/Abstract/334765 |
| Doi | http://dx.doi.org/10.1159/000334765 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | Default mode network; Extrastriate visual resting state network; Parkinson's disease dementia; Functional connectivity |
| Description | Aims: Using fMRI, we evaluated the default mode network (DMN) and the extrastriate visual resting state network (ESV-RSN) in 14 patients with Parkinson's disease dementia (PDD) as compared with 18 patients with Parkinson's disease (PD) without dementia and 18 healthy controls (HC). Methods: We analyzed the seed-based functional connectivity of both resting state data and deactivations during a visual complex scene-encoding task. Results: Using the posterior cingulate cortex/precuneus as a seed for the DMN analysis, we observed significant decreases of connectivity in the right inferior frontal gyrus in PDD as compared to PD and HC. Using the caudate nucleus as a seed for the ESV-RSN analysis, we found significant decreases of connectivity in the left and right inferior occipital gyrus in PDD as compared to HC. Conclusion: Differences in functional connectivity patterns between PDD and PD/HC were observed in areas known to be engaged in stimulus-driven reorienting of attention and in visual processing. Copyright (C) 2012 S. Karger AG, Basel |
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