PTP1B Is an Effector of Activin Signaling and Regulates Neural Specification of Embryonic Stem Cells

Investor logo

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

MATULKA Kamil LIN Hsuan-hwai HŘÍBKOVÁ Hana UWANOGHO Dafe DVOŘÁK Petr SUN Yuh-Man

Year of publication 2013
Type Article in Periodical
Magazine / Source Cell stem cell
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.sciencedirect.com/science/article/pii/S1934590913004463
Doi http://dx.doi.org/10.1016/j.stem.2013.09.016
Field Genetics and molecular biology
Keywords Activin/Nodal; protein tyrosine phosphatase 1B ; Activin/ALK4; p-ERK1/2 ;
Description During embryogenesis, the Activin/Nodal pathway promotes the mesendodermal lineage and inhibits neural fate. The molecular mechanisms underlying this role of the Activin/Nodal pathway are not clear. In this study, we report a role for protein tyrosine phosphatase 1B (PTP1B) in Activin-mediated early fate decisions during ESC differentiation and show that PTP1B acts as an effector of the Activin pathway to specify mesendodermal or neural fate. We found that the Activin/ALK4 pathway directly recruits PTP1B and stimulates its release from the endoplasmic reticulum through ALK4-mediated cleavage. Subsequently, PTP1B suppresses p-ERK1/2 signaling to inhibit neural specification and promote mesendodermal commitment. These findings suggest that a noncanonical Activin signaling pathway functions in lineage specification of mouse and human embryonic stem cells.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.