A Pencil Graphite Electrode In Situ Modified by Monovalent Copper: a Promising Tool for the Determination of Methylxanthines

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Authors

NAVRÁTIL Rudolf JELEN František KAYRAN Yasin Ugur TRNKOVÁ Libuše

Year of publication 2014
Type Article in Periodical
Magazine / Source Electroanalysis
MU Faculty or unit

Faculty of Science

Citation
Web http://dx.doi.org/10.1002/elan.201400017
Doi http://dx.doi.org/10.1002/elan.201400017
Field Physical chemistry and theoretical chemistry
Keywords Methylxanthines; Pencil graphite electrode; Elimination voltammetry; Copper-purine complexes
Description A pencil graphite electrode (PeGE) exhibits a promising tool for the electrochemical analysis of xanthine (Xan) and its N-methyl derivatives (1-, 3-, 7- and 9-mXan). The changes in their level in blood, serum, urine, as products of purine catabolism, can indicate the development of some diseases. Sensitivity-enhanced voltammetric detection of mXans was achieved by forming of complex with Cu(I) and application of elimination procedure. The Cu(I)-mXan complex was identified by means of titration of electrochemically produced cuprous ions by mXan. Our approach enables separation of overlapped mXan oxidation signals. Based on the obtained results, we found that the effect of methyl group position on the xanthine skeleton was significant and it was also discussed.
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