SENSITIVITY OF ACTION POTENTIAL TO CHANGES OF INWARD RECTIFIER POTASSIUM CURRENT IK1 IS DIFFERENT IN RECENT MODELS OF HUMAN VENTRICULAR CARDIOMYOCYTES
| Authors | |
|---|---|
| Year of publication | 2014 |
| Type | Article in Proceedings |
| Conference | Engineering Mechanics 2014 |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | Cardiac cell; Action potential; Inward rectifier potassium current; Quantitative modelling |
| Description | The inwardly rectifying potassium current IK1 is one of the principle ionic currents responsible for repolarization phase of mammalian action potentials (APs). To estimate the impact of individual ionic currents on AP configuration, mathematical models have been widely used. In this study, we compare the effects of alcohol-induced changes of IK1 on AP duration (APD) as simulated in four recently published computer models of human ventricular cells. As expected, increasing or decreasing IK1 conductance by 20% respectively caused a shortening or a lengthening of APD. However, the effect was largely model-dependent, ranging from 1% to about 15% change of APD. Given the conflicting available experimental data on the features of IK1 in human ventricular myocytes there is a need for a set of well-established end-point constraints for a reliable human ventricular myocyte model to be generated. |
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