Epigenetic Regulation of Telomere Maintenance

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Authors

FOJTOVÁ Miloslava FAJKUS Jiří

Year of publication 2014
Type Article in Periodical
Magazine / Source Cytogenetic and Genome research
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://www.karger.com/Article/Pdf/360775
Doi http://dx.doi.org/10.1159/000360775
Field Genetics and molecular biology
Keywords Chromatin; DNA methylation; Epigenetics; Histone modifications; Telomerase; Telomere; Telomeric transcripts
Description As chromatin structures, telomeres undergo epigenetic regulation of their maintenance and function. In plants, these processes are likely of a higher complexity than in animals or yeasts, as exemplified by methylation of cytosines in plant telomeric DNA or reversible developmental regulation of plant telomerase. We highlight the dual role of telomeres from the epigenetic point of view: (i) as chromatin structures that are the subject of epigenetic regulation (e. g. DNA and histone modifications), and (ii) as chromosome domains acting themselves as epigenetic regulatory elements (e. g. in the telomere position effect). Possibly, some molecular tools (e. g. telomeric transcripts) are common to both these aspects of telomere epigenetics. We further discuss the justification for the classical textbook view of telomeres as heterochromatic structures. (C) 2014 S. Karger AG, Basel
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