Computational fluid dynamics-based design of a microfabricated cell capture device.

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Authors

JÁRVÁS Gábor SZIGETI Marton HAJBA Laszlo FURJES Peter GUTTMAN Andras

Year of publication 2015
Type Article in Periodical
Magazine / Source Journal of Chromatographic Science
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://chromsci.oxfordjournals.org/content/53/3/411.long
Doi http://dx.doi.org/10.1093/chromsci/bmu110
Field Analytic chemistry
Keywords CIRCULATING TUMOR-CELLS; MICROFLUIDIC SYSTEMS; SEPARATION; POLY(DIMETHYLSILOXANE); MICROSPHERES
Description A microfluidic cell capture device was designed, fabricated, evaluated by numerical simulations and validated experimentally. The cell capture device was designed with a minimal footprint compartment comprising internal micropillars with the goal to obtain a compact, integrated bioanalytical system. The design of the device was accomplished by computational fluid dynamics (CFD) simulations. Various microdevice designs were rapidly prototyped in poly-dimethylsiloxane using conventional soft lithograpy technique applying micropatterned SU-8 epoxy based negative photoresist as moulding replica. The numerically modeled flow characteristics of the cell capture device were experimentally validated by tracing and microscopic recording the flow trajectories using yeast cells. Finally, we give some perspectives on how CFD modeling can be used in the early stage of microfluidics-based cell capture device development.
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