THE INFLUENCE OF VERTEX POTENTIAL AND MULTIPLE SCAN VOLTAMMETRY ON THE FORMATION OF 8-OXOGUANINE
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Proceedings |
| Conference | XV. Workshop of Physical Chemists and Electrochemists |
| MU Faculty or unit | |
| Citation | |
| Field | Physical chemistry and theoretical chemistry |
| Keywords | guanosine; guanosine - 5 - monophosphate; PeGE; cyclic voltammetry; EVP |
| Description | The electrochemical behavior of guanosine (Guo) and guanosine-5´-monophosphate (GMP) at pencil graphite electrode (PeGE) in the phosphate-acetic buffer is examined by cyclic voltammetry (CV). The oxidation peaks of both compounds appear at 1.1 V naturally, but using a multiple cycle we observed an additional peak. It was found that this peak corresponds to oxidation of 8-oxo-7,8-dihydroguanine (8-oG). To determine the potential of 8-oG formation we changed positive vertex potentials in the range from 0.9 to 1.4 V vs. Ag/AgCl/3MKCl reference electrode. The lowest vertex potential at which the 8-oG provided response corresponds to 1.3V for both Guo and GMP (pH 4.16). The most important is the fact that the appearance of the 8-oG peak always occurs after the first cycle of CV. |
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