Atopic phenotype associations with rs7927894 inter gene polymorphism on chromosome 11q13.5 in Czech adult patients with atopic dermatitis
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Global Dermatology |
| MU Faculty or unit | |
| Citation | |
| Web | http://oatext.com/Atopic-phenotype-associations-with-rs7927894-inter-gene-polymorphism-on-chromosome-11q135-in-Czech-adult-patients-with-atopic-dermatitis.php |
| Doi | http://dx.doi.org/10.15761/GOD.1000137 |
| Field | Other specializations of internal medicine |
| Keywords | atopic dermatitis; gene polymorphism; genotype-phenotype study; rs7927891 |
| Description | We did not observe significant differences in genotype distribution and/or allelic frequencies between AD men and women in polymorphism rs792894. But, the CT genotype of polymorphism rs7927894 on chromosome 11q13.5 was more than 4times more frequently observed in AD women with elevated levels of the total IgE above 158 IU/ml. In AD men, a significant association of polymorphism rs7927894 on chromosome 11q13.5 with atopic phenotype/ predisposition was found: the genotypes CC and TT are 6 times more frequent in AD men with other atopic phenotype (asthma, atopic rhinitis) compared to AD men without it. The TT genotype of the polymorphism was 4 times more frequent in men with positive family history of atopic phenotypes. |
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