Chromatin dynamics of plant telomeres and ribosomal genes

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Authors

DVOŘÁČKOVÁ Martina FOJTOVÁ Miloslava FAJKUS Jiří

Year of publication 2015
Type Article in Periodical
Magazine / Source The Plant Journal
MU Faculty or unit

Central European Institute of Technology

Citation
Web http://onlinelibrary.wiley.com/doi/10.1111/tpj.12822/epdf
Doi http://dx.doi.org/10.1111/tpj.12822
Field Genetics and molecular biology
Keywords telomere; rDNA; Arabidopsis thaliana; Nicotiana tabacum; chromatin; epigenetics
Attached files
Description Telomeres and genes encoding 45S ribosomal RNA (rDNA) are frequently located adjacent to each other on eukaryotic chromosomes. Although their primary roles are different, they show striking similarities with respect to their features and additional functions. Both genome domains have remarkably dynamic chromatin structures. Both are hypersensitive to dysfunctional histone chaperones, responding at the genomic and epigenomic levels. Both generate non-coding transcripts that, in addition to their epigenetic roles, may induce gross chromosomal rearrangements. Both give rise to chromosomal fragile sites, as their replication is intrinsically problematic. However, at the same time, both are essential for maintenance of genomic stability and integrity. Here we discuss the structural and functional inter-connectivity of telomeres and rDNA, with a focus on recent results obtained in plants.
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