Incorporation of humanized niche as a strategy for improving leukemic engraftment in immunodeficient mice
| Authors | |
|---|---|
| Year of publication | 2015 |
| Type | Article in Periodical |
| Magazine / Source | Transfuze a hematologie dnes |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | bone marrow; microenvironment; scaffold; biomaterial; leukemia; mesenchymal stromal cell |
| Description | In vivo models of patient derived leukemias are utilized using immunodeficient mice that provide engraftment of xeno--transplanted leukemic cells without their rejection. Despite the achievement of considerable immunosuppression in the latest immunecompromised mouse, engraftment of patient samples is still not always possible or does not fully reflect the original disease characteristics. This points to the presence of inter-species differences in the hematopoietic niche. In order to improve engraftment options, a valid proposition is to model the human niche in mice. In recent years, this has been performed by adopting an osteogenic approach already used in bone-regenerative medicine and based on using a suitable biomaterial along with mesenchymal stromal cells capable of bone-formation. The review aims to present and discuss works describing leukemic engraftment in a hybrid-mouse model containing a humanized microenvironment and to point out important details and possible future directions of this research. |
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