Acetaldehyde at Clinically Relevant Concentrations Inhibits Inward Rectifier Potassium Current I-K1 in Rat Ventricular Myocytes

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Authors	BÉBAROVÁ Markéta MATEJOVIČ Peter ŠIMURDOVÁ Milena ŠIMURDA Jiří
Year of publication	2015
Type	Article in Periodical
Magazine / Source	Physiological Research
MU Faculty or unit	Faculty of Medicine
Citation
Field	Physiology
Keywords	Acetaldehyde; Arrhythmias; Inward rectifier; IK1 inhibition; Rat ventricular myocytes
Description	Considering the effects of alcohol on cardiac electrical behaviour as well as the important role of the inward rectifier potassium current IK1 in arrhythmogenesis, this study was aimed at the effect of acetaldehyde, the primary metabolite of ethanol, on IK1 in rat ventricular myocytes. Acetaldehyde induced a reversible inhibition of IK1 with IC50 = 53.7 +/- 7.7 microM at -110 mV; a significant inhibition was documented even at clinically-relevant concentrations (at 3 microM by 13.1 +/- 3.0%). The inhibition was voltage-independent at physiological voltages above -90 mV. The IK1 changes under acetaldehyde may contribute to alcohol-induced alterations of cardiac electrophysiology, especially in individuals with a genetic defect of aldehyde dehydrogenase where the acetaldehyde level may be elevated.
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