Identification of metabolites of selected benzophenanthridine alkaloids and their toxicity evaluation

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Authors

SÁNDOR Roman MIDLIK Adam ŠEBRLOVÁ Kristýna DOVRTĚLOVÁ Gabriela NOSKOVÁ Kristýna JUŘICA Jan SLANINOVÁ Iva TÁBORSKÁ Eva PEŠ Ondřej

Year of publication 2016
Type Article in Periodical
Magazine / Source Journal of Pharmaceutical and Biomedical Analysis
MU Faculty or unit

Faculty of Medicine

Citation
Web http://www.sciencedirect.com/science/article/pii/S0731708516300255
Doi http://dx.doi.org/10.1016/j.jpba.2016.01.024
Field Biochemistry
Keywords benzophenanthridines; metabolites; rat liver microsomes; mass spectrometry; isolation
Description Selected benzo[c]phenathridine alkaloids were biotransformed using rat liver microsomes and identified by liquid chromatography and mass spectrometry. While the metabolites of commercially available sanguinarine and chelerythrine have been studied in detail, data about the metabolism of the minor alkaloids remained unknown. Reactions involved in transformation include single and/or double O-demethylation, demethylenation, reduction, and hydroxylation. Two metabolites, when isolated, purified and tested for toxicity, were found to be less toxic than the original compounds.
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