Newly identified lectin from Photorhabdus asymbiotica and its structure-functional study

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Authors	JANČAŘÍKOVÁ Gita DEMO Gabriel KOMÁREK Jan WIMMEROVÁ Michaela
Year of publication	2014
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	Our project is focused on study of a new lectin from the Photorabdus asymbiotica bacterium (PHL). Photorabdus asymbiotica belongs to the Photorabdus genus together with Photorabdus luminiscens and Photorabdus temperata. The latter 2 species are characterized as strictly virulent insect pathogens. In contrast, P. asymbiotica is also a human pathogen, which causes locally invasive soft tissue and disseminated bacterimic infections. We have identified a new putative lectin in the P. asymbiotica genome with the predicted structure similarity to the lectins from so-called AAL family, which are specific for fucosylated oligosaccharide. The AAL family contains AAL from Aleuria aurantia which inhibits a repair of epithelia or the RSL lectin from Ralstonia solanaccearum predicted as one of the key virulent factors of this plant pathogen.
Related projects:	CEITEC - Central European Institute of Technology Studium proteinu z patogenu zapojených do rozpoznávání hostitelského organismu