Způsob přímé mono-N-substituce piperazinu

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Title in English Process of direct piperazine mono-N-substitution
Authors

PAZDERA Pavel ZBEROVSKÁ Barbora HEROVÁ Dana

Year of publication 2016
Type Patent
MU Faculty or unit

Faculty of Science

Publisher Úřad průmyslového vlastnictví
State Czech Republic
Patent's number 305854
Web https://isdv.upv.cz/webapp/pts.det?xprim=1847727&lan=cs&s_majs=&s_puvo=&s_naze=&s_anot=
Description In the present invention, there is provided a disclosed a process of direct mono-N-substitution of piperazine in synthetically significant yields in a simple performance being characterized in that there is prepared piperazine-1 cation and subsequently under catalysis of a compound of a d-metal, aluminium or cerium, the piperazine-1 cation reacts with an electrophilic agent, preferably in the molar ratio of the piperazine-1 cation to the electrophilic agent in the range of 1:1 to 1:1.4.
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