Způsob přímé mono-N-substituce piperazinu
| Title in English | Process of direct piperazine mono-N-substitution |
|---|---|
| Authors | |
| Year of publication | 2016 |
| Type | Patent |
| MU Faculty or unit | |
| Publisher | Úřad průmyslového vlastnictví |
| State | Czech Republic |
| Patent's number | 305854 |
| Web | https://isdv.upv.cz/webapp/pts.det?xprim=1847727&lan=cs&s_majs=&s_puvo=&s_naze=&s_anot= |
| Description | In the present invention, there is provided a disclosed a process of direct mono-N-substitution of piperazine in synthetically significant yields in a simple performance being characterized in that there is prepared piperazine-1 cation and subsequently under catalysis of a compound of a d-metal, aluminium or cerium, the piperazine-1 cation reacts with an electrophilic agent, preferably in the molar ratio of the piperazine-1 cation to the electrophilic agent in the range of 1:1 to 1:1.4. |
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