MikroRNA u cerebrovaskulárních onemocnění - od patofyziologie k potenciálním biomarkerům
| Title in English | MicroRNAs in Cerebrovascular Diseases - from Pathophysiology to Potential Biomarkers |
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| Authors | |
| Year of publication | 2016 |
| Type | Article in Periodical |
| Magazine / Source | Česká a slovenská neurologie a neurochirurgie |
| MU Faculty or unit | |
| Citation | |
| Web | http://www.csnn.eu/ceska-slovenska-neurologie-clanek/mikrorna-u-cerebrovaskularnich-onemocneni-od-patofyziologie-k-potencialnim-bio-markerum-58254 |
| Field | Neurology, neurosurgery, neurosciences |
| Keywords | microRNA; ischemic stroke; intracranial aneurysma; cerebral arterio-venous malformations |
| Description | Small non-cod ing molecules of ribonucleic acid are important regulators of gene expres sion and translation. One group of non-cod ing RNAs is represented by microRNA – 22- 24 nucleotides long RNA molecules with eff ects on regulation of proteins synthesis. Many of them are tis sue or organ specifi c (e. g. miR-206 in striated muscles or miR-122 in hepatocytes). These molecules are enzyme- -resistant and detectable in both intracel lular and extracel lular space. Cur rently, these molecules are intensively studied as potential markers in many diseases includ ing cerebrovascular diseases. In this review we provide insight into the recent knowledge from animal to human studies concern ing miRNAs, with the special emphasis put on dia gnostic, therapeutic and prognostic potentials in ischemic stroke (let-7, miR-7, miR-21, miR-29, miR-124, miR-181, miR-210, miR-223), intracranial aneurysms (miR-21, miR-26, miR-29, miR-143/ 145), and brain arterio-venous malformations (miR-18a). |
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