Buněčná analýza plasmacytoidních dendritických buněk u mnohočetného myelomu

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Title in English Cellular analysis of plasmacytoid dendritic cells in Multiple Myeloma
Authors

KRÁLOVÁ Romana ŘÍHOVÁ Lucie VŠIANSKÁ Pavla KRCHNIAKOVÁ Mária PISKÁČEK Martin PACASOVÁ Rita PENKA Miroslav ADAM Zdeněk POUR Luděk HÁJEK Roman KNIGHT Andrea

Year of publication 2016
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Medicine

Citation
Description Plasmacytoid dendritic cells (pDCs) is a small population of leukocytes. They play important roles as antigen presenting cells in healthy organisms and thanks to their production of type I interferon they activate other cells of immune system to fight against tumour cells. Multiple Myeloma (MM) is a B cell malignancy that can be found in patients around 65 years old. Plasma cells are clonally expanded and they produce pathological immunoglobulin (paraprotein). PDCs support proliferation of myeloma cells and cause resistance against myeloma treatment.
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