Mitochondrial dysfunction in DDR-related cancer predisposition syndromes

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Authors

LYAKHOVICH Alex GRAIFER Dmitry ŠTEFANOVIE Barbora KREJČÍ Lumír

Year of publication 2016
Type Article in Periodical
Magazine / Source Biochimica et Biophysica Acta - Reviews on Cancer
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1016/j.bbcan.2016.02.006
Field Genetics and molecular biology
Keywords Mitochondrial dysfunction; DNA damage and repair; Cancer predisposition syndromes; Oxidative stress; ROS; Autophagy; Mitophagy
Description Given the key role of mitochondria in various cellular events, it is not surprising that mitochondrial dysfunction (MDF) is seen in many pathological conditions, in particular cancer. The mechanisms defining MDF are not clearly understood and may involve genetic defects, misbalance of reactive oxygen species (ROS), impaired autophagy (mitophagy), acquired mutations in mitochondrial or nuclear DNA and inability of cells to cope with the consequences. The importance of MDF arises from its detection in the syndromes with defective DNA damage response (DDR) and cancer predisposition. Here, we will focus on the dual role of these syndromes in cancer predisposition and MDF with specific emphasis on impaired autophagy. (C) 2016 Elsevier B.V. All rights reserved.
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