Vitamin D receptor TaqI gene polymorphism and dental caries in Czech children

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Authors

IZAKOVIČOVÁ HOLLÁ Lydie BOŘILOVÁ LINHARTOVÁ Petra KAŠTOVSKÝ Jakub BARTOŠOVÁ Michaela MUSILOVÁ Kristína KUKLA Lubomír KUKLETOVÁ Martina

Year of publication 2017
Type Article in Periodical
Magazine / Source Caries Research
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1159/000452635
Field ORL, ophthalmology, stomatology
Keywords case-control study; dental caries; gene polymorphism; Gingivitis; Vitamin D receptor
Description Aim: We analyzed the VDR TaqI (rs731236) gene polymorphism in children with and those without dental caries. Methods: A total of 388 subjects, 153 caries-free (with decayed/missing/filled teeth [DMFT] = 0) and 235 children with dental caries (DMFT >=1), were genotyped by the TaqMan method. Results: Although no significant differences in VDR TaqI allele and genotype frequencies between caries-free and caries-affected children were detected, a significant association between this polymorphism and gingivitis was found (p < 0.05). Conclusions: In contrast to previous studies from China and Turkey, the VDR TaqI gene variant cannot be used as a marker for identification of Czech children with increased dental caries risk.
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