Future paradigms for precision oncology

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Authors

KLEMENT Giannoula Lakka ARKUN Knarik VALÍK Dalibor ROFFIDAL Tina HASHEMI Ali KLEMENT Christos CARMASSI Paolo RIETMAN Edward SLABÝ Ondřej MAZÁNEK Pavel MÚDRY Peter KOVACS Gabor KISS Csongor NORGA Koen KONSTANTINOV Dobrin ANDRÉ Nicolas SLAVC Irene DEN BERG Henk van KOLENOVA Alexandra KŘEN Leoš TŮMA Jiří SKOTÁKOVÁ Jarmila ŠTĚRBA Jaroslav

Year of publication 2016
Type Article in Periodical
Magazine / Source Oncotarget
MU Faculty or unit

Faculty of Medicine

Citation
Web http://dx.doi.org/10.18632/oncotarget.9488
Doi http://dx.doi.org/10.18632/oncotarget.9488
Field Oncology and hematology
Keywords precision medicine; targeted therapy; genomics; metronomic chemotherapy
Description Research has exposed cancer to be a heterogeneous disease with a high degree of inter-tumoral and intra-tumoral variability. Individual tumors have unique profiles, and these molecular signatures make the use of traditional histology-based treatments problematic. The conventional diagnostic categories, while necessary for care, thwart the use of molecular information for treatment as molecular characteristics cross tissue types. This is compounded by the struggle to keep abreast the scientific advances made in all fields of science, and by the enormous challenge to organize, cross-reference, and apply molecular data for patient benefit. In order to supplement the site-specific, histology-driven diagnosis with genomic, proteomic and metabolomics information, a paradigm shift in diagnosis and treatment of patients is required. While most physicians are open and keen to use the emerging data for therapy, even those versed in molecular therapeutics are overwhelmed with the amount of available data. It is not surprising that even though The Human Genome Project was completed thirteen years ago, our patients have not benefited from the information. Physicians cannot, and should not be asked to process the gigabytes of genomic and proteomic information on their own in order to provide patients with safe therapies. The following consensus summary identifies the needed for practice changes, proposes potential solutions to the present crisis of informational overload, suggests ways of providing physicians with the tools necessary for interpreting patient specific molecular profiles, and facilitates the implementation of quantitative precision medicine. It also provides two case studies where this approach has been used.
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