Rational construction of macrocycles consisting of methylene bridged ureas

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Authors	YAWER Mirza Arfan NEČAS Marek ŠINDELÁŘ Vladimír
Year of publication	2016
Type	Article in Periodical
Magazine / Source	Tetrahedron
MU Faculty or unit	Faculty of Science
Citation
Web	http://www.sciencedirect.com/science/article/pii/S0040402016302630
Doi	http://dx.doi.org/10.1016/j.tet.2016.04.009
Field	Organic chemistry
Keywords	Macrocycles; Ureas; Triazinanones; Hydrogen bonding; Condensation
Attached files	rational_construction_of_new_macrocycles_2016.pdf
Description	Synthesis of two macrocycles formed by urea functions connected solely by methylene bridges is described. This is the first example of isolated and fully characterized macrocyclic compounds in which NH containing urea units are separated by methylene bridges. X-ray diffractometry revealed formation of multiple intramolecular hydrogen bonds between acidic NH and oxygen atoms of urea within the macrocycles.
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