18PTKI pazopanib impaires immunostimulatory properties of monocytes: Implication for monocyte-derived DC-based anti-cancer vaccine preparation

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Authors	ZDRAŽILOVÁ DUBSKÁ Lenka FĚDOROVÁ Lenka PILÁTOVÁ Kateřina MÚDRY Peter HLAVÁČKOVÁ Eva MATOULKOVÁ Eva FLAJŠAROVÁ Lucie DEMLOVÁ Regina VALÍK Dalibor ŠTĚRBA Jaroslav
Year of publication	2016
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	We manufacture fully personalized monocyte-derived dendritic cell-based vaccines that are evaluated in investigator-initiated clinical trial „Combined antitumor therapy with ex vivo manipulated dendritic cells producing interleukin-12 in children, adolescents and young adults with progressive, recurrent of primarily metastatic high-risk tumours”. Immunobiological part of quality control (QC) of DC batches revealed variability in immunostimulatory properties. We analyzed DC parametres within the context of patients medical history and explore the effect of anti-cancer compound on monocyte functional properties.
Related projects:	CZECRIN - Český národní uzel Evropské sítě infrastruktur klinického výzkumu