True Nondisjunction of Whole Bivalents in Oocytes with Attachment and Congression Defects
| Authors | |
|---|---|
| Year of publication | 2017 |
| Type | Article in Periodical |
| Magazine / Source | Cytogenetic and Genome research |
| MU Faculty or unit | |
| Citation | |
| Doi | http://dx.doi.org/10.1159/000458513 |
| Field | Genetics and molecular biology |
| Keywords | Aneuploidy; Bivalents; Chromosome congression; Chromosome segregation; Meiosis; Nondisjunction; Oocyte |
| Description | Chromosome segregation in mammalian oocytes is prone to errors causing aneuploidy with consequences such as precocious termination of development or severe developmental disorders. Aneuploidy also represents a serious problem in procedures utilizing mammalian gametes and early embryos in vitro. In our study, we focused on congression defects during meiosis I and observed whole nondisjoined bivalents in meiosis II as a direct consequence, together with a substantially delayed first polar body extrusion. We also show that the congression defects are accompanied by less stable attachments of the kinetochores. Our results describe a process by which congression defects directly contribute to aneuploidy. (C) 2017 S. Karger AG, Basel |
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