Evolution and functions of SMC complexes: new SMC5/6 insights

Investor logo
Authors

PALEČEK Jan GRUBER Stephan VONDROVÁ Lucie ADAMUS Marek ZÁBRADY Kateřina JURČIŠINOVÁ Lenka CRABBEN Saskia N van der HENNUS Marije P MCGREGOR Grant RITTER Deborah I LEHMANN Alan R OLIVER Antony W KOZLÍKOVÁ Barbora PLON Sharon E MURRAY Johanne M HAAFTEN Gijs van

Year of publication 2016
Type Requested lectures
Citation
Description The SMC (structure maintenance of chromosome) complexes are conserved from bacteria to humans (SMC/ScpAB and MukBEF in prokaryotes; cohesin, condensin and SMC5/6 in eukaryotes). They are critical for DNA replication, chromosome compaction and segregation, genome maintenance, and regulation of gene expression. We described marked structural similarities between bacterial SMC/ScpAB and eukaryotic SMC5/6 complexes (particularly their kite subunits). We discovered several important features of SMC5/6 kite subunits: their role in structural organization of the SMC5/6 complex, their DNA-binding ability, their evolution from bacteria to novel mammalian MAGE protein superfamily and new chromosome breakage syndrome associated with human Nse3-kite subunit mutations.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.

By clicking “Accept Cookies”, you agree to the storing of cookies on your device to enhance site navigation, analyze site usage, and assist in our marketing efforts. Cookie Settings

Necessary Only Accept Cookies