Umbilical cord blood and maternal visfatin (PBEF/NAMPT) concentrations in preterm birth with and without preterm premature rupture of membranes

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Authors

PAVLOVÁ Tereza ZLÁMAL Filip ŠPLÍCHAL Zbyněk TOMANDL Josef HODICKÁ Zuzana VENTRUBA Pavel BIENERTOVÁ VAŠKŮ Julie

Year of publication 2018
Type Article in Periodical
Magazine / Source JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1080/14767058.2017.1328493
Keywords Visfatin; PBEF; NAMPT; preterm birth; preterm premature rupture of membranes
Description Objectives: The aim of the study is to investigate differences in visfatin concentrations between mothers with term and preterm birth (PTB) and between mothers who delivered within seven days and after more than seven days following admission for PTB/preterm premature rupture of membranes (PPROMs).Methods: Maternal peripheral blood and cord blood were collected from 56 mothers with PTB (31 with PPROM) and 71 mothers with term delivery (three with PPROM).Results: Maternal visfatin concentration was significantly higher for given gestational age in PTBs compared to term deliveries (p=.021) and also in mothers who delivered within seven days after admission for PTB or PPROM, compared to those who delivered after more than seven days (p=.027; p=.039). Cord blood visfatin concentration was found to be decreased in preterm compared to term infants (p=.007).Conclusions: Visfatin in both maternal and fetal circulation may play an important role in the pathogenesis of PTB/PPROM and could be used to distinguish between women who will deliver in a short period of time after clinical presentation of PTB/PPROM and those who deliver later. Nevertheless, additional research is necessary in order to identify its direct involvement in PTB/PPROM.
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