Both ketamine and NBQX attenuate alcohol drinking in male Wistar rats

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.

Authors	RUDÁ Jana BABINSKÁ Zuzana ĽUPTÁK Matej GETACHEW Bruk TIZABI Yousef
Year of publication	2018
Type	Article in Periodical
Magazine / Source	Neuroscience Letters
MU Faculty or unit	Faculty of Medicine
Citation
web	https://www.sciencedirect.com/science/article/pii/S030439401731025X
Doi	http://dx.doi.org/10.1016/j.neulet.2017.12.055
Field	Pharmacology and pharmaceutical chemistry
Keywords	Alcoholism; Alcohol use disorder; Glutamatergic receptors; NMDA receptor; AMPA receptor; Kainate receptor
Description	Highlights: Acute low dose ketamine reduced alcohol intake but not alcohol-related behavioural effects. Acute low dose NBQX reduced alcohol intake but not alcohol-related behavioural effects. NMDA or AMPA/kainate receptor antagonists may have treatment potential in alcohol use disorder. These results suggest that selective antagonism of the NMDA or AMPA/kainate receptors may be of therapeutic potential in AUD.
Related projects:	Experimentální a translační farmakologický výzkum a vývoj Behaviorální psychofarmakologie a farmakokinetika v preklinickém výzkumu léčiv