Reanalysis of Chinese Treponema pallidum samples: all Chinese samples cluster with SS14-like group of syphilis-causing treponemes

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Authors	STROUHAL Michal OPPELT Jan MIKALOVÁ Lenka ARORA Natasha NIESELT Kay GONZÁLEZ-CANDELAS Fernando ŠMAJS David
Year of publication	2018
Type	Article in Periodical
Magazine / Source	BMC Research Notes
MU Faculty or unit	Faculty of Medicine
Citation
Web	https://bmcresnotes.biomedcentral.com/articles/10.1186/s13104-017-3106-7
Doi	http://dx.doi.org/10.1186/s13104-017-3106-7
Keywords	Genome sequencing; Phylogenetic analysis; Single nucleotide variant; SyphilisTreponema pallidum
Description	Treponema pallidum subsp. pallidum (TPA) is the causative agent of syphilis. Genetic analyses of TPA reference strains and human clinical isolates have revealed two genetically distinct groups of syphilis-causing treponemes, called Nichols-like and SS14-like groups. So far, no genetic intermediates, i.e. strains containing a mixed pattern of Nichols-like and SS14-like genomic sequences, have been identified. Recently, Sun et al. (Oncotarget 2016. https://doi.org/10.18632/oncotarget.10154) described a new “phylogenetic group” (called Lineage 2) among Chinese TPA strains. This lineage exhibited a “mosaic genomic structure” of Nichols-like and SS14-like lineages.
Related projects:	Molekulárně buněčná biologie pro biomedicínu Studium genomů patogenních treponem na základě analýzy jednotlivých buněk