Sekvenování nové generace u akutní myeloidní leukemie: Nový pohled na patogenezi a vývoj leukemických klonů

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Title in English Next generation sequencing in acute myeloid leukaemia: New insights into the pathogenesis and development of leukemic clones
Authors

ČULEN Martin KOSAŘOVÁ Zdeňka JEŽÍŠKOVÁ Ivana FOLTA A. DVOŘÁKOVÁ Dana SEMERÁD Lukáš ŠUSTKOVÁ Zuzana RÁČIL Zdeněk

Year of publication 2017
Type Article in Periodical
Magazine / Source Transfuze a hematologie dnes
MU Faculty or unit

Faculty of Medicine

Citation
Keywords AML; clonality; NGS; haematopoiesis; relapse
Description The pathogenesis of acute myeloid leukaemia is a gradual heterogeneous process induced in the majority of cases by multiple genetic aberrations The latest evidence shows that different genetic lesions play specific roles in this process cooperate with each other and are repeatedly found in a specific hierarchical order In many cases frank leukaemia is preceded by the development of non-malignant clonal haematopoiesis which transforms into a neoplastic process by the generation of further mutations The successive accumulation of mutations then produces leukemic sub-clones which may even constitute phenotypically different cell populations with different sensitivity to therapy and relapse-inducing ability This article aims to provide a concise review of the latest data on the kinetics of acute myeloid leukaemia generation and relapse and also on the role of somatic mutations most frequently involved in these processes.
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