Recurrent aphthous stomatitis and gene variability in selected interleukins
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| Year of publication | 2018 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Genetic factors, especially those related to the immune system functioning, have been intensively studied for their role in the development of recurrent aphthous stomatitis (RAS). The aim of the present study was to analyze gene variability in interleukins (ILs): IL-2, IL-4 and its receptor alpha (IL-4R alpha), IL-10 and IL-13, which were selected based on the literature review and/or their functional relevance, in Czech patients with RAS and healthy controls. Generally, 252 subjects were enrolled in this case-control study (178 controls and 74 patients with RAS) and their detail anamnestic, clinical and laboratory data were obtained. Nine polymorphisms in the genes encoding ILs were determined by PCR techniques. There were no significant differences in allele or genotype frequencies of the studied polymorphisms IL-2 (rs2069762 and rs2069763), IL-4 (rs2243250 and rs79071878), IL-4R alpha (rs1801275), IL-10 (rs1800896), and IL-13 (rs1800925) between the controls and RAS patients. The minority alleles of the IL-10 (rs1800871 and rs1800872) variants were associated with a higher risk of RAS , as confirmed by the results of genotype and haplotype analysis. We suggest that variability in the IL-10 gene may play an important role in the RAS development in the Czech population. |
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