Pyrazolotriazines as inhibitors of nucleases

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Authors	DAMBORSKÝ Jiří NIKULENKOV Fedor SISÁKOVÁ Alexandra HAVEL Štěpán KREJČÍ Lumír CARBAIN Benoit Jean-Pierre BREZOVSKÝ Jan DANIEL Lukáš PARUCH Kamil
Year of publication	2018
Type	Patent
MU Faculty or unit	Faculty of Science
Publisher	USPTO
State	United States of America
Patent's number	US 9969741 B2
Web	http://patft.uspto.gov/netacgi/nph-Parser?Sect2=PTO1&Sect2=HITOFF&p=1&u=/netahtml/PTO/search-bool.html&r=1&f=G&l=50&d=PALL&RefSrch=yes&Query=PN/9969741
Description	The present invention relates to substituted heterocycles as inhibitors of nudeases MUS81 and MRE11, pharmaceutical compositions containing the compounds, and pharmaceutical use of the compounds and compositions in the treatment of the diseases such as, for example, cancer.
Related projects:	Development of new MUS81 nuclease inhibitors as chemical biology probe with clinical progression CZ-OPENSCREEN: National Infrastructure for Chemical Biology