Current treatment of behavioral and cognitive symptoms of Parkinson's disease

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Authors

REKTOROVÁ Irena

Year of publication 2019
Type Article in Periodical
Magazine / Source Parkinsonism and Related Disorders
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://linkinghub.elsevier.com/retrieve/pii/S1353-8020(19)30087-2
Doi http://dx.doi.org/10.1016/j.parkreldis.2019.02.042
Keywords Apathy; Behavioral; Cognitive; Dementia; Dopaminergic; Impulse control disorders; Mild cognitive impairment; Parkinson's disease; Psychosis; treatment
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Description Cognitive and behavioral symptoms are common in Parkinson's disease, may occur even in the prodromal stages of the disease, worsen with disease progression, and surpass motor symptoms as the major factors affecting patient quality of life and caregiver burden. The symptoms may be caused by the disease pathology or they may represent adverse effects of treatment, or both etiological factors may contribute. Although many of these symptoms are related to dopaminergic dysfunction or dopaminergic medication, other neurotransmitters are involved as well. Behavioral symptoms including impulse control disorders, apathy, psychosis, as well as mild cognitive impairment and dementia are reviewed with a special focus on current treatment approaches.
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