Noninvasive Ventilatory Correction in Patients With Acute Ischemic Stroke A Systematic Review and Meta-Analysis

Warning

This publication doesn't include Faculty of Education. It includes Faculty of Medicine. Official publication website can be found on muni.cz.
Authors

TSIVGOULIS G. ALEXANDROV A. KATSANOS A.H. BARLINN K. MIKULÍK Robert LAMBADIARI V. BONAKIS A. ALEXANDROV A.W.

Year of publication 2017
Type Article in Periodical
Magazine / Source Stroke
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.ahajournals.org/doi/10.1161/STROKEAHA.117.017661
Doi http://dx.doi.org/10.1161/STROKEAHA.117.017661
Keywords acute ischemic stroke; bilevel positive airway pressure; continuous positive airway pressure; early neurological deterioration; noninvasive ventilatory correction
Description Background and Purpose-Even though current guidelines suggest that noninvasive ventilatory correction (NIVC) could be considered for acute ischemic stroke patients with obstructive sleep apnea, available evidence is conflicting, with no adequately powered randomized clinical trial being available to date. Methods-We conducted a systematic review and meta-analysis of all available literature data evaluating the effect of NIVC on neurological improvement (based on decrease in National Institutes of Health Stroke Scale score), vascular events (recurrent stroke, transient ischemic attack, myocardial infarction and unstable angina), and mortality during the followup period. Results-We identified 4 randomized clinical trials and 1 prospectively matched observational cohort, comprising a total of 389 patients (59.8% males, mean age: 64.4 years). The risk of both performance and detection bias was considered high in most of the included randomized clinical trials because of the lack of blinding in participants, personnel and/ or outcome assessors. The mean decrease in National Institutes of Health Stroke Scale scores during the first (<= 30) days of acute ischemic stroke was found to be greater in NIVC-treated patients in comparison to controls (standardized mean difference, 0.38; 95% confidence interval, 0.11-0.66; P= 0.007). However, no significant differences were detected between NIVC-treated acute ischemic stroke patients and controls on both the risk of vascular events (risk ratio, 0.53; 95% confidence interval, 0.25-1.14; P= 0.11) and mortality (risk ratio, 0.71; 95% confidence interval, 0.37-1.36; P= 0.30). No evidence of heterogeneity (I2= 0%; P for Cochran Q> 0.50) or publication bias were detected in all analyses. Conclusions-NIVC seems to be associated with greater short-term neurological improvement in acute ischemic stroke patients with obstructive sleep apnea. This finding deserves further investigation within the settings of an adequately powered, sham-control, randomized clinical trial.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.