NANO-GOLD APPLICATIONS IN MALDI TOF MS OF PEPTIDES

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Authors

RUSNÁKOVÁ Lenka HAVEL Josef

Year of publication 2011
Type Article in Proceedings
Conference BIOLOGICALLY ACTIVE PEPTIDES
MU Faculty or unit

Faculty of Science

Citation
Web https://doi.org/10.1135/css201113120
Doi http://dx.doi.org/10.1135/css201113120
Keywords Nano-gold; Peptides; MALDI TOF MS; Microextraction
Description Gold particles (dimensions are ranging from 1 to several hundreds of nm) called nano-gold (NG) interact with DNA, nucleotides, peptides, proteins, etc. They are applied for tissue coloring, cellular detection, drug-delivery, detection and treatment of cancer, etc. In this work the use of NG in mass spectrometry of peptides was studied. It was found that (i) NG can be used as a matrix for peptide ionization, (ii) Au-n(+) clusters formed can be in the same time used as internal calibrants, and (iii) NG can also be used for peptide micropxtraction and consequent MALDI analysis.
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