AC Pulsed Field Ablation Is Feasible and Safe in Atrial and Ventricular Settings: A Proof-of-Concept Chronic Animal Study

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Authors	CALUORI Guido ODEHNALOVÁ Eva JADCZYK Tomasz PEŠL Martin PAVLOVÁ Iveta VALÍKOVÁ Lucia HOLZINGER Steffen NOVOTNÁ Veronika ROTREKL Vladimír HAMPL Aleš CRHA Michal ČERVINKA Dalibor STÁREK Zdeněk
Year of publication	2020
Type	Article in Periodical
Magazine / Source	Frontiers in bioengineering and biotechnology
MU Faculty or unit	Faculty of Medicine
Citation
web	https://www.frontiersin.org/articles/10.3389/fbioe.2020.552357/full
Doi	http://dx.doi.org/10.3389/fbioe.2020.552357
Keywords	pulsed field ablation; irreversible electroporation (IRE); radiofrequency ablation; atrial fibrillation; ventricular arrhythmia (VA); preclinical cardiology
Description	Pulsed field ablation (PFA) exploits the delivery of short high-voltage shocks to induce cells death via irreversible electroporation. The therapy offers a potential paradigm shift for catheter ablation of cardiac arrhythmia. We designed an AC-burst generator and therapeutic strategy, based on the existing knowledge between efficacy and safety among different pulses. We performed a proof-of-concept chronic animal trial to test the feasibility and safety of our method and technology.
Related projects:	National research infrastructure for biological and medical imaging