Effects of low-dose alcohol exposure in adolescence on subsequent alcohol drinking in adulthood in a rat model of depression
| Authors | |
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| Year of publication | 2021 |
| Type | Article in Periodical |
| Magazine / Source | The World Journal of Biological Psychiatry |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.tandfonline.com/doi/full/10.1080/15622975.2021.1907717 |
| Doi | http://dx.doi.org/10.1080/15622975.2021.1907717 |
| Keywords | Alcohol use disorder; AMPA/kainate receptor; Depression; NBQX; Olfactory bulbectomy; Rats |
| Description | Adolescence drinking and subsequent development of alcohol use disorder (AUD) is a worldwide health concern. In particular, mood dysregulation or early alcohol exposure can be the cause of heavy drinking in some individuals or a consequence of heavy drinking in others. This study investigated the effects of voluntary alcohol intake during adolescence, i.e. continuous 10% alcohol access between postnatal days (PND) 29 to 43 and olfactory bulbectomy (OBX) model of depression (performed on PND 59) on alcohol drinking in Wistar rats during adulthood (PND 80-120, intermittent 20% alcohol access). In addition, the effect of NBQX, an AMPA/kainate receptor antagonist (5?mg/kg, IP) on spontaneous alcohol consumption was examined. |
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