Mass Spectrometry Imaging Techniques Enabling Visualization of Lipid Isomers in Biological Tissues

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Authors

BEDNAŘÍK Antonín PRYSIAZHNYI Vadym BEZDEKOVÁ Dominika SOLTWISCH Jens DREISEWERD Klaus PREISLER Jan

Year of publication 2022
Type Article in Periodical
Magazine / Source Analytical Chemistry
MU Faculty or unit

Faculty of Science

Citation
Web https://pubs.acs.org/doi/10.1021/acs.analchem.1c05108
Doi http://dx.doi.org/10.1021/acs.analchem.1c05108
Keywords mass spectrometry imaging; lipid isomers; double bond position; sn-position; chemical derivatization; biological tissues
Description The feature article focuses on a review of recent developments in mass spectrometry imaging (MSI) of lipid isomers in biological tissues. The tandem MS techniques utilizing on-line and off-line chemical derivatization procedures, ion activation techniques such as ozone-induced dissociation (OzID), ultraviolet photodissociation (UVPD), or electron-induced dissociation (EID), and other techniques such as coupling of ion mobility with MSI are discussed. The importance of resolving lipid isomers in diseases is highlighted.
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