Interaction of five gene polymorphism at psoriasis

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Authors

VAŠKŮ Vladimír VAŠKŮ Anna IZAKOVIČOVÁ HOLLÁ Lydie KAŇKOVÁ Kateřina ZNOJIL Vladimír SEMRÁDOVÁ Věra VÁCHA Jiří

Year of publication 1999
Type Article in Periodical
Magazine / Source The Journal of Investigative Dermatology
MU Faculty or unit

Faculty of Medicine

Citation
Field Dermatovenerology
Keywords gene; polymorphism; TAP; TNF; endothelin; ACE
Description Associations among five gene polymorphism interactions and clinically manifested psoriasis were studied. All studied gene polymorphisms (endothelin-1-ET-1, transporters associated with antigen processing-TAP1, tumor necrosis factor beta-TNF beta, angiotensin I converting enzyme-ACE, advanced glycosylation end product-specific receptor- RAGE) were analyzed for their possible participation in the MHC class I cell surface antigen presentation to CD8+ T-cells. In psoriatic patients (n=153), the disequilibrium was found for coincidence of TNF beta with TAPl-333 ( P=0.016) as well as with TAP1-637 ( P=0.035). TNF beta was in disequilibrium with (ACE) polymorphism (P=0.036). ACE was observed to be in tight disequilibrium with TAP1-333 (p= 0.009) but not with TAP1-637 (P=0.133). The borderline significance of disequilibrium was found for ET-1 and RAGE gene polymorphisms (P=0.07).
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