Aberrations induced in chromosome 1, 2 and Y of human lymphocytes by three types of radiation of different LET value as detected by FISH
| Authors | |
|---|---|
| Year of publication | 1999 |
| Type | Article in Proceedings |
| Conference | Fundamentals for the assesment of risks from environmental radiation |
| MU Faculty or unit | |
| Citation | |
| Field | Biophysics |
| Description | Fluorescence in situ hybridisation was used to determine the efficiency of the induction of aberrations in chromosomes 1, 2 and Y of human lymphocytes by gamma-rays, fast neutrons of mean energy of 7 MeV and accelerated nitrogen ions. The frequency and the spectrum of aberration types induced by these three types of radiation were different. Nitrogen ions induced the highest number of aberrations. The most frequent were chromosome fragments followed by centric rings. Neutrons and gamma-rays induced most frequently translocations followed by dicentric chromosomes. Efficiency of neutrons in the induction of aberrations was higher in comparison with gamma-rays. Induction of aberrations by both gamma-rays and fast neutrons in Y chromosome was much less effective in comparison with chromosome 1. The low efficiency of these types of radiation in the induction of aberrations in Y chromosome is probably related to the lower content of DNA in this chromosome and to its higher content of heterochromatin. |
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