Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

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Authors

BERNAL Kevin TOUMA Charbel ERRADHOUANI Chedi BORONAT-BELDA Talia GAILLARD Lucas AL KASSIR Sara LE MENTEC Helene MARTIN-CHOULY Corinne PODECHARD Normand LAGADIC-GOSSMANN Dominique LANGOUET Sophie BRION Francois KNOLL-GELLIDA Anja BABIN Patrick J. SOVADINOVÁ Iva BABICA Pavel ANDREAU Karine BAROUKI Robert VONDRACEK Jan ALONSO-MAGDALENA Paloma BLANC Etienne KIM Min Ji COUMOUL Xavier

Year of publication 2022
Type Article in Periodical
Magazine / Source FEBS Letters
MU Faculty or unit

Faculty of Science

Citation
Web https://febs.onlinelibrary.wiley.com/doi/10.1002/1873-3468.14465
Doi http://dx.doi.org/10.1002/1873-3468.14465
Keywords appetite; bisphenol; dioxin; inflammation; insulin resistance; microbiota; perfluorinated compounds; phthalate; TBT
Attached files
Description The prevalence of metabolic diseases, such as obesity, diabetes, metabolic syndrome and chronic liver diseases among others, has been rising for several years. Epidemiology and mechanistic (in vivo, in vitro and in silico) toxicology have recently provided compelling evidence implicating the chemical environment in the pathogenesis of these diseases. In this review, we will describe the biological processes that contribute to the development of metabolic diseases targeted by metabolic disruptors, and will propose an integrated pathophysiological vision of their effects on several organs. With regard to these pathomechanisms, we will discuss the needs, and the stakes of evolving the testing and assessment of endocrine disruptors to improve the prevention and management of metabolic diseases that have become a global epidemic since the end of last century.
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