Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy

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Authors

ZLÍNSKÁ Vladimíra MATOUSEK Vaclav TRANTÍREK Lukáš RIGO Riccardo

Year of publication 2022
Type Article in Periodical
Magazine / Source ALDRICHIMICA ACTA
MU Faculty or unit

Central European Institute of Technology

Citation
Web https://www.sigmaaldrich.com/CZ/en/collections/aldrichimica-acta
Keywords F-19 NMR spectroscopy; F-19 probes; DNA; RNA; F-19-labeling approaches; nucleic acid folding; nucleic acid/small molecule interactions; nucleic acid/protein interactions; in vitro; in vivo
Description This mini-review provides an overview of approaches to F-19-labeling of nucleic acids. A special attention is paid to applications of F-19-labeled nucleic acids to resolve their polymorphism and characterize their folding and interactions with ligands and proteins in vitro and in living cells by using NMR spectroscopy.
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