Fluorine Labeling as a Versatile Tool for Probing Nucleic Acid Folding and Interactions by NMR Spectroscopy

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Authors	ZLÍNSKÁ Vladimíra MATOUSEK Vaclav TRANTÍREK Lukáš RIGO Riccardo
Year of publication	2022
Type	Article in Periodical
Magazine / Source	ALDRICHIMICA ACTA
MU Faculty or unit	Central European Institute of Technology
Citation
Web	https://www.sigmaaldrich.com/CZ/en/collections/aldrichimica-acta
Keywords	F-19 NMR spectroscopy; F-19 probes; DNA; RNA; F-19-labeling approaches; nucleic acid folding; nucleic acid/small molecule interactions; nucleic acid/protein interactions; in vitro; in vivo
Description	This mini-review provides an overview of approaches to F-19-labeling of nucleic acids. A special attention is paid to applications of F-19-labeled nucleic acids to resolve their polymorphism and characterize their folding and interactions with ligands and proteins in vitro and in living cells by using NMR spectroscopy.
Related projects:	Atomically resolved in vivo NMR spectroscopy as a novel tool for biological testing of therapeutically important genomic non-canonical DNA targets and their interactions with drugs in phenotypically diversified cancer cells. MSCAfellow4@MUNI