Brain metabolic derangements examined using 1H MRS and their (in)consistency among different rodent models of depression

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Authors

PAVLOVA Iveta RUDÁ Jana

Year of publication 2023
Type Article in Periodical
Magazine / Source PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
MU Faculty or unit

Faculty of Medicine

Citation
Web https://www.sciencedirect.com/science/article/pii/S0278584623000945?via%3Dihub
Doi http://dx.doi.org/10.1016/j.pnpbp.2023.110808
Keywords Animal models Depression Proton magnetic resonance spectroscopy Metabolites
Attached files
Description This review summarises the current knowledge of 1H MRS findings from rodent models of MDD, assesses the results from both a biological and a technical perspective, and identifies the main sources of bias. From a technical point of view, bias-introducing factors are the diversity of the measured volumes and their positioning in the brain, the data processing, and the metabolite concentration expression.
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