Brain metabolic derangements examined using 1H MRS and their (in)consistency among different rodent models of depression
| Authors | |
|---|---|
| Year of publication | 2023 |
| Type | Article in Periodical |
| Magazine / Source | PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY |
| MU Faculty or unit | |
| Citation | |
| Web | https://www.sciencedirect.com/science/article/pii/S0278584623000945?via%3Dihub |
| Doi | http://dx.doi.org/10.1016/j.pnpbp.2023.110808 |
| Keywords | Animal models Depression Proton magnetic resonance spectroscopy Metabolites |
| Attached files | |
| Description | This review summarises the current knowledge of 1H MRS findings from rodent models of MDD, assesses the results from both a biological and a technical perspective, and identifies the main sources of bias. From a technical point of view, bias-introducing factors are the diversity of the measured volumes and their positioning in the brain, the data processing, and the metabolite concentration expression. |
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